3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

Base Information

Chemical Name:3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone
CAS No.:126401-45-4
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

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Chemical Property of 3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

Chemical Property:

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Technology Process of 3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

There total 3 articles about 3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95798-31-5
(4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one

: 5437-45-6
Benzyl bromoacetate

: 126401-45-4
3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

Guidance literature:: With n-butyllithium; ammonium chloride; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 126401-45-4
3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, n-hexane, -78 deg C, 30 min; 2.) THF, 1 h

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 1 h; 2.) THF, 5 h, at -78 deg C -> 0 deg C

With n-butyllithium; lithium diisopropyl amide;
DOI:10.1248/cpb.37.2200

Reference yield:

: 95798-31-5
(4S)-3-(3-phenylpropionyl)-4-(2-propyl)oxazolidin-2-one

: 5437-45-6
Benzyl bromoacetate

: 126401-46-5
(S)-3-Benzyl-4-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-4-oxo-butyric acid benzyl ester

: 126401-45-4
3-<2-(R)-benzyl-3-(benzyloxycarbonyl)propionyl>-4-(S)-isopropyl-2-oxazolidinone

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 deg C, 1 h; 2.) THF, 5 h, at -78 deg C -> 0 deg C;
DOI:10.1248/cpb.37.2200