1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆

Base Information

• Chemical Name: 1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆
• CAS No.: 1538556-42-1
• Molecular Formula: C₇H₇BrO
• Molecular Weight: 192.97
• Mol file: 1538556-42-1.mol

Synonyms:1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆

Chemical Property of 1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆

There total 2 articles about 1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

anisole-1,2,3,4,5,6-13C6 (152571-52-3,154492-88-3) → 1-bromo-4-methoxybenzene-1,2,3,4,5,6-13C6 (1538556-42-1)

Guidance literature:

With Selectfluor; sodium bromide; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2020.131352

Reference yield:

[13C6]phenol (89059-34-7) → 1-bromo-4-methoxybenzene-1,2,3,4,5,6-13C6 (1538556-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h / Inert atmosphere

1.2: 1 h / 0 - 50 °C / Inert atmosphere

2.1: N-Bromosuccinimide / chloroform; N,N-dimethyl-formamide / 70 °C

With N-Bromosuccinimide; sodium hydroxide; In chloroform; water; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3193

Reference yield: 100.0%

Triisopropyl borate (5419-55-6) + 1-bromo-4-methoxybenzene-1,2,3,4,5,6-13C6 (1538556-42-1) → (4-methoxyphenyl-1,2,3,4,5,6-13C6)boronic acid

Guidance literature:

1-bromo-4-methoxybenzene-1,2,3,4,5,6-¹³C₆; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -75 ℃; for 1.25h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -60 ℃; for 0.5h; Inert atmosphere;

With methanol; Glauber's salt; In tetrahydrofuran; hexane; toluene; at -50 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.tet.2020.131352

upstream raw materials:

anisole-1,2,3,4,5,6-¹³C₆

[¹³C₆]phenol

Downstream raw materials:

C₄⁽¹³⁾C₆H₁₁NO₄

C₄⁽¹³⁾C₆H₁₃NO₄

[¹³C₆]-4-methoxyphenyl-2-propanone

1,4-dimethoxy-[¹³C₆]-benzene