6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

Base Information

Chemical Name:6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene
CAS No.:1312037-39-0
Molecular Formula:C₂₃H₂₅NO₂S
Molecular Weight:379.523
Hs Code.:

Synonyms:6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

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Chemical Property of 6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

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Technology Process of 6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

There total 5 articles about 6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1312037-31-2
N-(3-(3, 5-dimethylphenyl)prop-2-yn-1-yl)-4-methyl-N-(penta-1,4-dien-3-yl)benzenesulfonamide

: 1312037-39-0
6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

Guidance literature:: With silver(I) tetrafluoroborate; C₃₉H₃₃IN₂PPt; In toluene; at 60 ℃; for 20h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201000904

Reference yield:

: 1312037-31-2
N-(3-(3, 5-dimethylphenyl)prop-2-yn-1-yl)-4-methyl-N-(penta-1,4-dien-3-yl)benzenesulfonamide

: 6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

: 1312037-39-0
6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

Guidance literature:: With silver hexafluoroantimonate; C₇₆H₅₆AuClNO₂P; In toluene; at 0 ℃; for 24h; Overall yield = 95 %; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201504658

Reference yield:

: 1152172-75-2
1-(3-bromoprop-1-ynyl)-3,5-dimethylbenzene

: 1312037-39-0
6-(3,5-dimethylphenyl)-3-(p-toluenesulfonyl)-2-vinyl-3-azabicyclo[4.1.0]hept-4-ene

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 60 °C

2: silver(I) tetrafluoroborate; C₃₉H₃₃IN₂PPt / toluene / 20 h / 60 °C / Inert atmosphere

With silver(I) tetrafluoroborate; C₃₉H₃₃IN₂PPt; potassium carbonate; In toluene; acetonitrile;
DOI:10.1002/adsc.201000904