1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

Base Information

Chemical Name:1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)
CAS No.:123903-70-8
Molecular Formula:C₁₆H₁₇FN₃O₉P
Molecular Weight:445.298
Hs Code.:

Synonyms:1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

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Chemical Property of 1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

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Technology Process of 1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

There total 4 articles about 1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 777-52-6
1-dichlorophosphoryloxy-4-nitro-benzene

: 123903-61-7
1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine

: 123903-70-8
1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

Guidance literature:: With pyridine; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1021/jm00164a035

Reference yield:

: 123903-57-1
(R,R)-2-(chloromethoxy)-1,3-bis(benzyloxy)-4-fluorobutane

: 123903-70-8
1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) tetrabutylammonium iodide / 1.) reflux, 2.) CH₂Cl₂, reflux, 24 h

2: 91.4 percent / 20percent Pd(OH)2/C, cyclohexene / ethanol / 15 h / Heating

3: 66 percent / pyridine / acetonitrile / 24 h / Ambient temperature

With pyridine; palladium dihydroxide; ammonium sulfate; tetra-(n-butyl)ammonium iodide; 1,1,1,3,3,3-hexamethyl-disilazane; cyclohexene; In ethanol; acetonitrile;
DOI:10.1021/jm00164a035

Reference yield:

: 123903-59-3
1-<<1,3(R)-bis(benzyloxy)-4-fluoro-2(R)-butoxy>methyl>thymine

: 123903-70-8
1-<(1,3(R)-dihydroxy-4-fluoro-2(R)-butoxy)methyl>thymine 1',3'-(cyclic p-nitrophenyl phosphate)

Guidance literature:: Multi-step reaction with 2 steps

1: 91.4 percent / 20percent Pd(OH)2/C, cyclohexene / ethanol / 15 h / Heating

2: 66 percent / pyridine / acetonitrile / 24 h / Ambient temperature

With pyridine; palladium dihydroxide; cyclohexene; In ethanol; acetonitrile;
DOI:10.1021/jm00164a035