(15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether

Base Information

• Chemical Name: (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether
• CAS No.: 1030358-21-4
• Molecular Formula: C₃₀H₃₄O₄
• Molecular Weight: 458.598
• Mol file: 1030358-21-4.mol

Synonyms:(15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether

Chemical Property of (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether

There total 2 articles about (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 15α-allyl-3-benzyloxyestra-1,3,5(10)-trien-17-one (534572-92-4) → (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether (1030358-21-4)

Guidance literature:

ion exchange immobilized Hoveyda-type catalyst; In dichloromethane; at 40 ℃; for 8h;

DOI:10.1016/j.tetlet.2008.02.134

Reference yield: 94.0%

crotonic acid methyl ester (623-43-8) + 15α-allyl-3-benzyloxyestra-1,3,5(10)-trien-17-one (534572-92-4) → (15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether (1030358-21-4)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 2.5h;

DOI:10.1016/j.tetlet.2008.02.134

Reference yield:

(15S)-(E-but-2-enic acid methyl ester)-3-estrone benzyl ether (1030358-21-4) → C30H34F2O3

Guidance literature:

With diethylamino-sulfur trifluoride;

upstream raw materials:

crotonic acid methyl ester

15α-allyl-3-benzyloxyestra-1,3,5(10)-trien-17-one

acrylic acid methyl ester