3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Base Information

Chemical Name:3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester
CAS No.:1070292-87-3
Molecular Formula:C₂₆H₂₃NO₄
Molecular Weight:413.473
Hs Code.:

Synonyms:3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

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Chemical Property of 3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

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Technology Process of 3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

There total 6 articles about 3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1036712-58-9
6-bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

: 1070292-87-3
3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 95 ℃; for 17h;

Reference yield:

: 1070292-84-0
6-bromo-2-(4-methoxybenzyl)-4H-isoquinoline-1,3-dione

: 1070292-87-3
3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol; dichloromethane / 2 h

1.2: 0.5 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 95 °C

With sodium tetrahydroborate; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 943749-63-1
4-bromo-2-(carboxymethyl)benzoic acid

: 1070292-87-3
3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride / acetone / 17 h / 20 °C

2.1: acetic acid / toluene / 17 h / Heating / reflux

3.1: sodium tetrahydroborate / methanol; dichloromethane / 2 h

3.2: 0.5 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 95 °C

With sodium tetrahydroborate; potassium carbonate; acetic acid; acetyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;