Technology Process of (3S,5S)-3,5-Dimethyl-1-(phenylmethyl)piperazin-2-one
There total 6 articles about (3S,5S)-3,5-Dimethyl-1-(phenylmethyl)piperazin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-N-<2--1-methylethyl>-L-alanine methyl ester;
With
hydrogenchloride; palladium on activated charcoal;
In
ethanol;
for 2h;
under 2068.65 Torr;
With
toluene-4-sulfonic acid;
In
ethanol;
at 90 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NEt3 / tetrahydrofuran / 48 h / Ambient temperature
2: 96 percent / TFA / CH2Cl2 / 1.) 0 deg C, 1 h; 2.) room temp., 18 h
3: 1.) BH3-DMS; 2.) 50percent aq. KOH / 1.) THF, room temp., 48 h, 2.) reflux, 24 h
4: NEt3 / CH2Cl2 / 1.) 0 deg C, 2 h; 2.) room temp., 2 h
5: 1.) conc. aq. HCl, H2, 2.) p-toluenesulfonic acid / 1.) 5percent Pd/C / 1.) EtOH, 4 psi, 2 h, 2.) EtOH, reflux, 16 h
With
hydrogenchloride; potassium hydroxide; dimethylsulfide borane complex; hydrogen; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00118a039
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / TFA / CH2Cl2 / 1.) 0 deg C, 1 h; 2.) room temp., 18 h
2: 1.) BH3-DMS; 2.) 50percent aq. KOH / 1.) THF, room temp., 48 h, 2.) reflux, 24 h
3: NEt3 / CH2Cl2 / 1.) 0 deg C, 2 h; 2.) room temp., 2 h
4: 1.) conc. aq. HCl, H2, 2.) p-toluenesulfonic acid / 1.) 5percent Pd/C / 1.) EtOH, 4 psi, 2 h, 2.) EtOH, reflux, 16 h
With
hydrogenchloride; potassium hydroxide; dimethylsulfide borane complex; hydrogen; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
dichloromethane;
DOI:10.1021/jo00118a039
