2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone

Base Information

• Chemical Name: 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone
• CAS No.: 286454-82-8
• Molecular Formula: C₂₆H₂₉NO₄
• Molecular Weight: 419.521
• Mol file: 286454-82-8.mol

Synonyms:2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone

Chemical Property of 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone

There total 4 articles about 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1R,2S)-2-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanol → 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone (286454-82-8)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃;

DOI:10.1016/S0040-4039(00)00421-4

Reference yield:

trans-4-Hydroxystilbene (6554-98-9) → 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone (286454-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 97 percent / KOH / dimethylformamide / 12 h / 25 °C

2.1: NBS; H₂O / dimethylsulfoxide / 0.5 h / 10 °C

2.2: 54 percent / aq. KOH / 0.5 h / 20 °C

3.1: 82 percent / CuI / 12 h / -40 - 20 °C

4.1: 80 percent / (CO)2Cl₂; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

With potassium hydroxide; N-Bromosuccinimide; oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; copper(l) iodide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Alkylation / 2.1: Addition / 2.2: Elimination / 3.1: Grignard reaction / 4.1: Oxidation;

DOI:10.1016/S0040-4039(00)00421-4

Reference yield:

(E)-N,N-dimethyl-2-(4-styrylphenoxy)ethanamine (101717-72-0) → 2-[4-(2-dimethylamino-ethoxy)-phenyl]-2-(4-methoxymethoxy-phenyl)-1-phenyl-ethanone (286454-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NBS; H₂O / dimethylsulfoxide / 0.5 h / 10 °C

1.2: 54 percent / aq. KOH / 0.5 h / 20 °C

2.1: 82 percent / CuI / 12 h / -40 - 20 °C

3.1: 80 percent / (CO)2Cl₂; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

With N-Bromosuccinimide; oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; copper(l) iodide; In dichloromethane; dimethyl sulfoxide; 1.1: Addition / 1.2: Elimination / 2.1: Grignard reaction / 3.1: Oxidation;

DOI:10.1016/S0040-4039(00)00421-4

upstream raw materials:

trans-4-Hydroxystilbene

(E)-N,N-dimethyl-2-(4-styrylphenoxy)ethanamine

Downstream raw materials:

tetradecanoic acid 4-[4-(2-dimethylamino-ethoxy)-phenyl]-3-hydroxy-4-(4-methoxymethoxy-phenyl)-3-phenyl-1-tetradecanoyloxymethyl-butyl ester

1-[4-(2-dimethylamino-ethoxy)-phenyl]-1-(4-methoxymethoxy-phenyl)-2-phenyl-pent-4-en-2-ol