Technology Process of 3-(4-methylpiperazin-1-yl)-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-7-(trifluoromethyl)quinolin-5-amine
There total 6 articles about 3-(4-methylpiperazin-1-yl)-N-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-7-(trifluoromethyl)quinolin-5-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane;
at 110 ℃;
for 12h;
Inert atmosphere;
DOI:10.1039/c1ob05830d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.5 h / 100 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 135 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: iron; ammonium chloride / ethanol; water / Inert atmosphere; Reflux
4.1: sodium hydroxide / ethanol / 1 h / 78 °C / Inert atmosphere
5.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); hydrogen bromide; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide dimethyl acetal; sodium hydroxide; sodium nitrite;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
4.1: Friedlaender synthesis;
DOI:10.1039/c1ob05830d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diammonium sulfide / ethanol / 8.5 h / Reflux; Inert atmosphere
2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere
2.2: 0.5 h / 100 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 135 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: iron; ammonium chloride / ethanol; water / Inert atmosphere; Reflux
5.1: sodium hydroxide / ethanol / 1 h / 78 °C / Inert atmosphere
6.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere
With
diammonium sulfide; tris-(dibenzylideneacetone)dipalladium(0); hydrogen bromide; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide dimethyl acetal; sodium hydroxide; sodium nitrite;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
5.1: Friedlaender synthesis;
DOI:10.1039/c1ob05830d
