Ethyl 4-[methyl(nitroso)amino]benzoate

Base Information

Chemical Name:Ethyl 4-[methyl(nitroso)amino]benzoate
CAS No.:208176-48-1
Molecular Formula:C₁₀H₁₂N₂O₃
Molecular Weight:208.217
Hs Code.:
DSSTox Substance ID:DTXSID901292069
Nikkaji Number:J971.201A

Synonyms:208176-48-1;DTXSID901292069;Ethyl 4-(methylnitrosoamino)benzoate

Suppliers and Price of Ethyl 4-[methyl(nitroso)amino]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl 4-[methyl(nitroso)amino]benzoate

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:208.08479225
Heavy Atom Count:15
Complexity:225

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC=C(C=C1)N(C)N=O

Technology Process of Ethyl 4-[methyl(nitroso)amino]benzoate

There total 6 articles about Ethyl 4-[methyl(nitroso)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 257946-79-5
ethyl 4-N-cyclopropyl-N-methylaminobenzoate

: 208176-48-1
ethyl 4-N-methyl-N-nitrosoaminobenzoate

Guidance literature:: With sodium nitrite; In water; acetic acid; at 0 ℃;
DOI:10.1021/jo991104z

Reference yield:

: 10541-82-9
ethyl 4-(methylamino)benzoate

: 208176-48-1
ethyl 4-N-methyl-N-nitrosoaminobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / Et₃N / CH₂Cl₂ / 88 h / Heating

2: 64 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 43 h / 20 °C

3: 76 percent / NaNO₂ / acetic acid; H₂O / 0 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; triethylamine; sodium nitrite; In tetrahydrofuran; dichloromethane; water; acetic acid; 1: Substitution / 2: Reduction / 3: Nitrosation;
DOI:10.1021/jo991104z

Reference yield:

: 257946-75-1
ethyl 4-N-(1-ethoxycyclopropyl)methylaminobenzoate

: 208176-48-1
ethyl 4-N-methyl-N-nitrosoaminobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 43 h / 20 °C

2: 76 percent / NaNO₂ / acetic acid; H₂O / 0 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium nitrite; In tetrahydrofuran; water; acetic acid; 1: Reduction / 2: Nitrosation;
DOI:10.1021/jo991104z