N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

Base Information

Chemical Name:N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester
CAS No.:773156-72-2
Molecular Formula:C₃₄H₃₉N₃O₈
Molecular Weight:617.699
Hs Code.:

<i>N</i>-(2,3-dimethoxy-benzyl)-3-[2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid <i>tert</i>-butyl ester

Synonyms:N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

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Chemical Property of N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

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Technology Process of N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

There total 4 articles about N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 773156-71-1
3-amino-N-(2,3-dimethoxy-benzyl)-succinamic acid tert-butyl ester

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 773156-72-2
N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: N-(fluoren-9-ylmethoxycarbonyl)glycine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 2h;

3-amino-N-(2,3-dimethoxy-benzyl)-succinamic acid tert-butyl ester; In dichloromethane; N,N-dimethyl-formamide; for 72h;
DOI:10.1002/chem.200400144

Reference yield:

: 773156-70-0
N-(2,3-dimethoxy-benzyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

: 773156-72-2
N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / piperidine / CH₂Cl₂

2.1: i-Pr₂NEt; HBTU / CH₂Cl₂; dimethylformamide / 2 h

2.2: 79 percent / CH₂Cl₂; dimethylformamide / 72 h

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200400144

Reference yield:

: 4393-09-3
2,3-dimethoxybenzyl amine

: 773156-72-2
N-(2,3-dimethoxy-benzyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: i-Pr₂NEt; HBTU / dimethylformamide; CH₂Cl₂ / 2 h

1.2: 90 percent / dimethylformamide; CH₂Cl₂

2.1: 100 percent / piperidine / CH₂Cl₂

3.1: i-Pr₂NEt; HBTU / CH₂Cl₂; dimethylformamide / 2 h

3.2: 79 percent / CH₂Cl₂; dimethylformamide / 72 h

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200400144