4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

Base Information

Chemical Name:4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate
CAS No.:849935-46-2
Molecular Formula:C₂₈H₃₀F₃N₃O₆
Molecular Weight:561.558
Hs Code.:

Synonyms:4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

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Chemical Property of 4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

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Technology Process of 4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

There total 4 articles about 4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 158726-30-8
3-trifluoroacetyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 849935-44-0
4-nitrobenzyl 4-(3-chloro-3-oxopropyl)piperidine-1-carboxylate

: 849935-46-2
4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

Guidance literature:: With aluminium trichloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2005.01.022

Reference yield:

: 86208-07-3
3-(1-{[(4-nitrobenzyl)oxy]carbonyl}piperidin-4-yl)propanoic acid

: 849935-46-2
4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / thionyl chloride / 1 h / 20 °C

2: 36 percent / AlCl₃ / CH₂Cl₂ / 12 h / 20 °C

With aluminium trichloride; thionyl chloride; In dichloromethane; 2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.01.022

Reference yield:

: 51052-79-0
3-(4-piperidinyl)propionic acid hydrochloride

: 849935-46-2
4-nitrobenzyl 4-{3-oxo-3-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]propyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / KOH / tetrahydrofuran; H₂O / 12 h / 20 °C

2: 83 percent / thionyl chloride / 1 h / 20 °C

3: 36 percent / AlCl₃ / CH₂Cl₂ / 12 h / 20 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; In tetrahydrofuran; dichloromethane; water; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.01.022