2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

Base Information

Chemical Name:2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide
CAS No.:1161355-70-9
Molecular Formula:C₂₃H₁₈F₆N₂O
Molecular Weight:452.399
Hs Code.:

Synonyms:2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

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Chemical Property of 2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

Chemical Property:

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Technology Process of 2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

There total 4 articles about 2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161355-29-8
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

: 1161355-70-9
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

: 1161355-25-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

Guidance literature:: With Chiralcel OD-H; In ethanol; Resolution of racemate;
DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

: 216059-91-5
4-(2-methylpyridin-4-yl)phenylamine

: 1161355-70-9
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

: 1161355-25-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

2: Chiralcel OD-H / ethanol / Resolution of racemate

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1161355-70-9
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

: 1161355-25-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 130 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

3: Chiralcel OD-H / ethanol / Resolution of racemate

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.09.041