1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

Base Information

Chemical Name:1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea
CAS No.:1347008-63-2
Molecular Formula:C₂₀H₁₅F₃N₆O₃
Molecular Weight:444.373
Hs Code.:

Synonyms:1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

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Chemical Property of 1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

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Technology Process of 1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

There total 5 articles about 1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1225278-32-9
C₁₅H₁₁F₃N₄O

: 5-methyl-3-isoxazoleisocyanate

: 1347008-63-2
1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.05.051

Reference yield:

: 19235-89-3
4-chloro-pyridine-2-carbonitrile

: 1347008-63-2
1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere

2.2: 20 h / 85 °C / Inert atmosphere

3.1: sulfuric acid; water / 5 h / 85 °C / Inert atmosphere

3.2: 20 °C / pH 8 - 9 / Inert atmosphere

4.1: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With sulfuric acid; ammonium acetate; water; sodium methylate; potassium carbonate; triethylamine; In propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1347008-63-2
1-(5-methylisoxazol-3-yl)-3-(4-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C

1.2: 1 h / 7 °C

2.1: triethylamine; trifluoroacetic anhydride / ethyl acetate / 1.25 h / -5 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

4.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere

4.2: 20 h / 85 °C / Inert atmosphere

5.1: sulfuric acid; water / 5 h / 85 °C / Inert atmosphere

5.2: 20 °C / pH 8 - 9 / Inert atmosphere

6.1: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With thionyl chloride; sulfuric acid; ammonium acetate; water; sodium methylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; In propan-1-ol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051