3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

Base Information

Chemical Name:3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole
CAS No.:1431510-16-5
Molecular Formula:C₂₃H₁₈N₂O₂S
Molecular Weight:386.474
Hs Code.:

Synonyms:3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

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Chemical Property of 3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

Chemical Property:

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Technology Process of 3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

There total 6 articles about 3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1431510-13-2
N-[4-iodo-1-(phenylsulfonyl)indol-5-yl]trifluoroacetamide

: 766-97-2
4-n-methylphenylacetylene

: 1431510-16-5
3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 110 ℃; for 5h; Inert atmosphere;
DOI:10.1007/s00706-012-0859-5

Reference yield:

: 1431510-12-1
4-iodo-1-(phenylsulfonyl)indol-5-amine

: 1431510-16-5
3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 110 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-012-0859-5

Reference yield:

: 124400-51-7
5-nitro-1-(phenylsulfonyl)-1H-indole

: 1431510-16-5
3,6-dihydro-2-(4-methylphenyl)-6-(phenylsulfonyl)pyrrolo-[3,2-e]indole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate; palladium 10% on activated carbon / methanol / 6 h / Reflux

2: N-iodo-succinimide / dichloromethane / 1.5 h / -5 °C

3: triethylamine / dichloromethane / 2 h / 0 °C

4: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 110 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; palladium 10% on activated carbon; hydrazine hydrate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-012-0859-5