(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

Base Information

Chemical Name:(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate
CAS No.:886458-14-6
Molecular Formula:C₂₄H₃₀N₂O₇
Molecular Weight:458.511
Hs Code.:

Synonyms:(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

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Chemical Property of (N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

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Technology Process of (N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

There total 3 articles about (N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 97699-68-8
2-(6-methoxynaphthalen-2-yl)propionic acid carboxymethyl ester

: cyclohexyl(2-(nitrooxy)ethyl)ammonium nitrate

: 886458-14-6
(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2005.11.040

Reference yield:

: 646509-90-2
((tert-butyl)oxycarbonyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

: 886458-14-6
(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / trifluoroacetic acid / CH₂Cl₂ / 48 h / 20 °C

2: 42 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 3 h / 0 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2005.11.040

Reference yield:

: 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

: 886458-14-6
(N-cyclohexyl-N-(2-(nitrooxy)ethyl)carbamoyl)methyl (2S)-2-(6-methoxy(2-naphthyl))propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaHCO₃ / dimethylformamide / 48 h / 20 °C

2: 66 percent / trifluoroacetic acid / CH₂Cl₂ / 48 h / 20 °C

3: 42 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 3 h / 0 °C

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.040