methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

Base Information

Chemical Name:methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate
CAS No.:1357474-47-5
Molecular Formula:C₂₁H₁₉ClN₂O₆S
Molecular Weight:462.911
Hs Code.:

Synonyms:methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

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Chemical Property of methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

Chemical Property:

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Technology Process of methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

There total 2 articles about methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1313023-74-3
N-(2-chloro-3-formyl-7-phenoxyquinolin-6-yl)methanesulfonamide

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1357474-47-5
methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 32h; Neat (no solvent);
DOI:10.1002/jhet.801

Reference yield:

: 220542-27-8
C₁₅H₁₆N₂O₄S

: 1357474-47-5
methyl 2-((2-chloro-6-(methylsulfonamido)-7-phenoxyquinolin-3-yl)(hydroxy)methyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate

2: 1,4-diaza-bicyclo[2.2.2]octane / 32 h / 20 °C / Neat (no solvent)

With 1,4-diaza-bicyclo[2.2.2]octane; trichlorophosphate; 2: Morita-Baylis-Hillman reaction;
DOI:10.1002/jhet.801