1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate
CAS No.:871339-14-9
Molecular Formula:C₁₆H₂₃ClN₂O₃
Molecular Weight:326.823
Hs Code.:

Synonyms:1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

There total 5 articles about 1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 871339-13-8
2-chloro-5-methyl-4-piperazine-1-ylphenol

: 24424-99-5
di-tert-butyl dicarbonate

: 871339-14-9
1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: In ethyl acetate; at 50 ℃; for 2h;

Reference yield:

: 871339-11-6
1-chloro-4-methyl-2-[(phenyl-methyl)oxy]aniline

: 871339-14-9
1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / diethylene glycol dimethyl ether / 18 h / Heating / reflux

2: trifluoroacetic acid / 3 h / Heating / reflux

3: ethyl acetate / 2 h / 50 °C

With potassium carbonate; trifluoroacetic acid; In diethylene glycol dimethyl ether; ethyl acetate;

Reference yield:

: 871339-12-7
1-{5-chloro-2-methyl-4-[(phenyl-methyl)oxy]phenyl}piperazine

: 871339-14-9
1,1-dimethylethyl 4-(5-chloro-4-hydroxy-2-methylphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 3 h / Heating / reflux

2: ethyl acetate / 2 h / 50 °C

With trifluoroacetic acid; In ethyl acetate;