(+)-2α-hydroxy-3α-tosyloxypinane

Base Information

• Chemical Name: (+)-2α-hydroxy-3α-tosyloxypinane
• CAS No.: 22553-34-0
• Molecular Formula: C₁₇H₂₄O₄S
• Molecular Weight: 324.441
• Mol file: 22553-34-0.mol

Synonyms:(+)-2α-hydroxy-3α-tosyloxypinane

Chemical Property of (+)-2α-hydroxy-3α-tosyloxypinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-2α-hydroxy-3α-tosyloxypinane

There total 3 articles about (+)-2α-hydroxy-3α-tosyloxypinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R,2R,3S,5R)-2,3-pinane diol (22422-34-0) + p-toluenesulfonyl chloride (98-59-9) → (1R,2R,3S,5R)-3-O-(4-toluenesulfonyl)-pinanediol (22553-34-0,22625-83-8,25926-75-4,38301-45-0,62860-26-8,22339-18-0)

Guidance literature:

With 2-Aminoethoxydiphenylborane; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 23 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja302549c

Reference yield: 93.0%

pinanediol (18680-27-8) + p-toluenesulfonyl chloride (98-59-9) → (+)-2α-hydroxy-3α-tosyloxypinane (22553-34-0)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

Reference yield:

→ (1R,2R,3S,5R)-3-O-(4-toluenesulfonyl)-pinanediol (22553-34-0,22625-83-8,25926-75-4,38301-45-0,62860-26-8,22339-18-0)

Guidance literature:

(-)-cis-α-Pinenglykol (1), p-Toluolsulfonylchlorid in Py.;

upstream raw materials:

(1R,2R,3S,5R)-2,3-pinane diol

p-toluenesulfonyl chloride

pinanediol

Downstream raw materials:

pinanediol

3β-methyl-2-nopinone