N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride

Base Information

• Chemical Name: N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride
• CAS No.: 1456621-40-1
• Molecular Formula: C₂₄H₃₀Cl₂N₄O₄*ClH
• Molecular Weight: 545.894
• Mol file: 1456621-40-1.mol

Synonyms:N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride

Chemical Property of N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride

There total 7 articles about N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N²,N²-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

N1,N1-bis(2-chloroethyl)benzene-1,2-diamine (13686-21-0) + 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline (183322-18-1) → N1-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N2,N2-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride (1456621-40-1)

Guidance literature:

In isopropyl alcohol; at 80 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

Ethyl protocatechuate (3943-89-3) → N1-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N2,N2-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride (1456621-40-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate; tetrabutylammomium bromide / acetonitrile

2: acetic acid; nitric acid / 0 °C

3: hydrogen; palladium on activated charcoal / methanol

4: 165 - 170 °C

5: trichlorophosphate / toluene

6: isopropyl alcohol / 0.67 h / 80 °C / Inert atmosphere

With palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; nitric acid; potassium carbonate; acetic acid; trichlorophosphate; In methanol; isopropyl alcohol; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one (179688-29-0) → N1-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N2,N2-bis(2-chloroethyl)benzene-1,2-diamine hydrochloride (1456621-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / toluene

2: isopropyl alcohol / 0.67 h / 80 °C / Inert atmosphere

With trichlorophosphate; In isopropyl alcohol; toluene;

DOI:10.1016/j.ejmech.2013.06.055

upstream raw materials:

N¹,N¹-bis(2-chloroethyl)benzene-1,2-diamine

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Ethyl protocatechuate

3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester