Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:170451-76-0
Molecular Formula:C₄₉H₆₄N₇O₇PSSi
Molecular Weight:954.215
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Suppliers and Price of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 6 articles about Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 293300-97-7
6-S-(2-cyanoethyl)-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-6-thioinosine

: 170451-76-0
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 18h;
DOI:10.1016/0040-4039(95)00805-M

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 170451-76-0
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / pyridine / 6 h / 20 °C

2: 96 percent / N-methylpyrrolidine / CH₂Cl₂ / 2 h / 20 °C

3: 27 percent / imidazole / dimethylformamide / 24 h / 20 °C

4: 76 percent / N-methylimidazole; collidine / tetrahydrofuran / 0.67 h / 20 °C

With 1-Methylpyrrolidine; 1H-imidazole; 1-methyl-1H-imidazole; 2,3,5-trimethyl-pyridine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution / 3: silylation / 4: Substitution;
DOI:10.1021/jo991432z

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 170451-76-0
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-cyano-ethylsulfanyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / pyridine / 6 h / 20 °C

2: 96 percent / N-methylpyrrolidine / CH₂Cl₂ / 2 h / 20 °C

3: 27 percent / imidazole / dimethylformamide / 24 h / 20 °C

4: 76 percent / N-methylimidazole; collidine / tetrahydrofuran / 0.67 h / 20 °C

With 1-Methylpyrrolidine; 1H-imidazole; 1-methyl-1H-imidazole; 2,3,5-trimethyl-pyridine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution / 3: silylation / 4: Substitution;
DOI:10.1021/jo991432z