3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

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Chemical Name:3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]
CAS No.:1449137-70-5
Molecular Formula:C₂₇H₃₂N₄O₄
Molecular Weight:476.575
Hs Code.:

Synonyms:3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

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Chemical Property of 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

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Technology Process of 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

There total 7 articles about 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 767351-04-2
(R)-1-(6-methoxypyridin-3-yl)propylamine

: 1449136-94-0
8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carboxylic acid

: 1449137-70-5
3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

Guidance literature:: 8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 2.66667h;

(R)-1-(6-methoxypyridin-3-yl)propylamine; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 2941-20-0,3082-64-2,3789-59-1,35600-74-9
1-phenylpropylamine

: 1449137-70-5
3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 50 °C

1.2: 25 °C

2.1: dichloromethane / 20 - 40 °C

3.1: sodium hydroxide; water / tetrahydrofuran / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2.67 h / 25 °C

4.2: 25 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1449136-92-8
6-(2,2,2-trichloroacetyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide

: 1449137-70-5
3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6,8-dicarboxylic acid 6-{[(R)-1-(6-methoxypyridin-3-yl)propyl]amide} 8-[((R)-1-phenylpropyl)amide]

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2.67 h / 25 °C

2.2: 25 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;