methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

Base Information

Chemical Name:methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate
CAS No.:1350658-97-7
Molecular Formula:C₁₉H₁₆F₂N₈O₂*H₂O₄S
Molecular Weight:524.465
Hs Code.:

Synonyms:methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

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Chemical Property of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

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Technology Process of methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

There total 11 articles about methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

: 1350653-20-1
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-5-yl}carbamate

: 1350658-97-7
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

Guidance literature:: With sulfuric acid; In 1,4-dioxane; isopropyl alcohol; at 20 ℃;

Reference yield:

: 113237-20-0
2,6-dichloro-5-fluoropyridine-3-carboxamide

: 1350658-97-7
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: zinc; acetic acid / methanol / 24 h / Reflux

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

3.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

4.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / -10 - 0 °C

4.2: 0.5 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

7.1: hydrogen; pyridine / palladium 10% on activated carbon / 20 °C

8.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: sulfuric acid / isopropyl alcohol; 1,4-dioxane / 20 °C

With pyridine; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 791644-48-9
2-chloro-5-fluoronicotinonitrile

: 1350658-97-7
methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate sulphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

2.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / -10 - 0 °C

2.2: 0.5 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

5.1: hydrogen; pyridine / palladium 10% on activated carbon / 20 °C

6.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

7.1: sulfuric acid / isopropyl alcohol; 1,4-dioxane / 20 °C

With pyridine; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol;