6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione

Base Information

• Chemical Name: 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione
• CAS No.: 348622-54-8
• Molecular Formula: C₂₂H₂₁ClN₂O₆S
• Molecular Weight: 476.938

Synonyms:6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione

Chemical Property of 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione

Chemical Property:

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Technology Process of 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione

There total 5 articles about 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ⁶-thia-2,3-diaza-spiro[4.5]decane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-1,1-dioxo-5-phenyl-tetrahydro-1λ6-thiopyran-4,4-dicarboxylic acid dimethyl ester (348622-42-4) → 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ6-thia-2,3-diaza-spiro[4.5]decane-1,4-dione (348622-54-8)

Guidance literature:

With sodium methylate; hydrazine hydrate; In methanol; for 10h; Heating;

DOI:10.1002/hc.1021

Reference yield:

1-chloro-3-(4-chlorophenyl)-3-oxoprop-1-ene (15787-85-6) → 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ6-thia-2,3-diaza-spiro[4.5]decane-1,4-dione (348622-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol; H₂O / 3 h / 0 - 10 °C

2: 88 percent / p-toluenesulfonic acid / benzene / 15 h / Heating

3: 74 percent / Triton-B / benzene / 4 h / Heating

4: 68 percent / sodium methoxide; hydrazine hydrate / methanol / 10 h / Heating

With sodium methylate; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; In methanol; water; benzene;

DOI:10.1002/hc.1021

Reference yield:

sodium (E)-styrenesulfinate → 6-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-8,8-dioxo-10-phenyl-8λ6-thia-2,3-diaza-spiro[4.5]decane-1,4-dione (348622-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol; H₂O / 3 h / 0 - 10 °C

2: 88 percent / p-toluenesulfonic acid / benzene / 15 h / Heating

3: 74 percent / Triton-B / benzene / 4 h / Heating

4: 68 percent / sodium methoxide; hydrazine hydrate / methanol / 10 h / Heating

With sodium methylate; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; hydrazine hydrate; In methanol; water; benzene;

DOI:10.1002/hc.1021

upstream raw materials:

3-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-1,1-dioxo-5-phenyl-tetrahydro-1λ⁶-thiopyran-4,4-dicarboxylic acid dimethyl ester

1-chloro-3-(4-chlorophenyl)-3-oxoprop-1-ene

1-(p-chlorobenzoyl)-2-styrylsulfonylethene

1-[2'-(4-chlorophenyl)-1',3'-dioxolano]-2-styrylsulfonylethene

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