(S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide

Base Information

• Chemical Name: (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide
• CAS No.: 1261228-25-4
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.314
• Mol file: 1261228-25-4.mol

Synonyms:(S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide

Chemical Property of (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide

There total 2 articles about (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl ((S)-1-(((RS)-2-hydroxy-1-phenylethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate → (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide (1261228-25-4) + N-1-[(1R)-2-hydroxy-1-phenylethyl]-(2S)-2-amino-3-methylbutanamide (620594-25-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr;

DOI:10.1016/j.tet.2018.03.006

Reference yield:

tert-butyl N-[(1S)-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)-2-methylpropyl]carbamate (496838-62-1) → (S)-2-amino-N-((S)-2-hydroxy-1-phenylethyl)-3-methylbutyramide (1261228-25-4)

Guidance literature:

With hydrogenchloride; In methanol; water; at 0 ℃; for 3h;

DOI:10.1002/adsc.201000419

upstream raw materials:

tert-butyl N-[(1S)-1-({[(1S)-2-hydroxy-1-phenylethyl]amino}carbonyl)-2-methylpropyl]carbamate