Technology Process of 6-(2',5'-dimethoxyphenyl)-2-pyridylmethylbromide
There total 6 articles about 6-(2',5'-dimethoxyphenyl)-2-pyridylmethylbromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.1039/b207406k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -40 °C
1.2: 75 percent / hexane; diethyl ether / 2 h / -70 °C
2.1: 82 percent / Pd(PPh3)4; sodium carbonate / toluene; H2O; methanol / 8 h / Heating
3.1: 95 percent / sodium borohydride / methanol / 0.25 h / Heating
4.1: 78 percent / phosphorous tribromide / CH2Cl2 / 3 h / 20 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; phosphorus tribromide; sodium carbonate;
In
methanol; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1039/b207406k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / Pd(PPh3)4; sodium carbonate / toluene; H2O; methanol / 8 h / Heating
2: 95 percent / sodium borohydride / methanol / 0.25 h / Heating
3: 78 percent / phosphorous tribromide / CH2Cl2 / 3 h / 20 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); phosphorus tribromide; sodium carbonate;
In
methanol; dichloromethane; water; toluene;
DOI:10.1039/b207406k
