1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

Base Information

Chemical Name:1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil
CAS No.:203437-50-7
Molecular Formula:C₂₇H₂₅ClN₂O₉
Molecular Weight:556.957
Hs Code.:

Synonyms:1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

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Chemical Property of 1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

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Technology Process of 1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

There total 4 articles about 1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 203437-48-3
1-(3',5'-di-O-benzoyl-2'-hydroxy-β-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

: 203437-50-7
1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

Guidance literature:: With thionyl chloride; In acetonitrile; for 1.5h; Heating;

Reference yield:

: 29571-46-8
ethyl 2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate

: 203437-50-7
1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: (NH₄)2SO₄ / 4 h / Heating

2: 70 percent / Me₃SiOSO₂CF₃ / acetonitrile / room t.

3: 68 percent / NH₃ / methanol / 2.5 h / 0 °C

4: 98 percent / SOCl₂ / acetonitrile / 1.5 h / Heating

With ammonium sulfate; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; ammonia; In methanol; acetonitrile; 1: Alkylation / 2: Alkylation / 3: Deacetylation / 4: Chlorination;

Reference yield:

: 203437-46-1
1-(2'-O-acetyl-3',5'-di-O-benzoyl-β-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

: 203437-50-7
1-(3',5'-di-O-benzoyl-2'-chloro-2'-deoxyβ-D-xylofuranosyl)-5-(ethoxycarbonylmethyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / NH₃ / methanol / 2.5 h / 0 °C

2: 98 percent / SOCl₂ / acetonitrile / 1.5 h / Heating

With thionyl chloride; ammonia; In methanol; acetonitrile; 1: Deacetylation / 2: Chlorination;