1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid
CAS No.:1490390-45-8
Molecular Formula:C₁₈H₁₁F₅N₂O₂
Molecular Weight:382.29
Hs Code.:

Synonyms:1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

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Chemical Property of 1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

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Technology Process of 1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

There total 4 articles about 1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₅F₅N₂O₂

: 1490390-45-8
1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 50 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.07.054

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 1490390-45-8
1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / methyl cyclohexane / 3 h / 20 °C

1.2: 16 h

1.3: Cooling with ice; Reflux

2.1: potassium hydroxide / ethanol / 12 h / 50 °C

With potassium hydroxide; lithium hexamethyldisilazane; In ethanol; methyl cyclohexane;
DOI:10.1016/j.ejmech.2013.07.054

Reference yield:

: 40594-30-7
2,4-difluorophenylhydrazine

: 1490390-45-8
1-(2,4-difluorophenyl)-4-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / methyl cyclohexane / 3 h / 20 °C

1.2: 16 h

1.3: Cooling with ice; Reflux

2.1: potassium hydroxide / ethanol / 12 h / 50 °C

With potassium hydroxide; lithium hexamethyldisilazane; In ethanol; methyl cyclohexane;
DOI:10.1016/j.ejmech.2013.07.054