(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

Base Information

Chemical Name:(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one
CAS No.:126764-92-9
Molecular Formula:C₃₀H₄₄O₃Si₂
Molecular Weight:508.849
Hs Code.:

Synonyms:(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

Suppliers and Price of (4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

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Technology Process of (4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

There total 6 articles about (4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 139055-95-1
(2R,4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-ol

: 126764-92-9
(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

Guidance literature:: With 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1039/P19910003301

Reference yield:

: 126764-90-7
Methyl 4-<(4R,6R)-4,6-dimethyl-1,3-dioxan-2-yl>propanoate

: 126764-92-9
(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / TiCl₄, molecular sieves 4A / CH₂Cl₂ / 0.33 h / -78 °C

2: 96 percent / LiAlH₄ / diethyl ether / 6 h / -72 deg C to room temperature

3: 80 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

4: 90 percent / pyridinium chlorochromate (PCC), NaOAc, 3A molecular sieves / CH₂Cl₂ / 15 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; 3 A molecular sieve; 4 A molecular sieve; sodium acetate; titanium tetrachloride; pyridinium chlorochromate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39890001025

Reference yield:

: 139055-94-0
(4R)-4-<(1R,3R)-3-Hydroxy-1-methylbutoxy>-6-trimethylsilylhex-5-yn-1-ol

: 126764-92-9
(4R)-4-<4-tert-Butyldiphenylsilyloxy-1-(2-trimethylsilylethynyl)butoxy>pentan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

2: 90 percent / pyridinium chlorochromate (PCC), NaOAc, 3A molecular sieves / CH₂Cl₂ / 15 h / Ambient temperature

With 1H-imidazole; 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39890001025