2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

Base Information

Chemical Name:2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate
CAS No.:650625-27-7
Molecular Formula:C₂₅H₃₉N₃O₆
Molecular Weight:477.601
Hs Code.:

Synonyms:2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

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Chemical Property of 2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

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Technology Process of 2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

There total 9 articles about 2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 650625-32-4
2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-benzyloxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

: 650625-27-7
2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃;
DOI:10.1002/hlca.200390262

Reference yield:

: 4835-90-9
3-Hydroxy-2,2-dimethylpropanoic acid

: 650625-27-7
2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93 percent / tetrahydrofuran / 24 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

2.2: 66 percent / Na-imidazolide / tetrahydrofuran / 20 °C

3.1: 89 percent / H₂ / Pd/C / 20 °C

With hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1002/hlca.200390262

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 650625-27-7
2-methyl-2-{N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]carbamoyl}propyl 2-[(3-hydroxy-2,2-dimethylpropanoyl)amino]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 47 percent / NaH / tetrahydrofuran / 3 h / Heating

2.1: 88 percent / aq. KOH / ethanol / 1 h / 20 °C

3.1: 84 percent / tetrahydrofuran / 24 h

4.1: 89 percent / aq. HCl / tetrahydrofuran / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

5.2: 66 percent / Na-imidazolide / tetrahydrofuran / 20 °C

6.1: 89 percent / H₂ / Pd/C / 20 °C

With hydrogenchloride; potassium hydroxide; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1002/hlca.200390262