(2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide

Base Information

• Chemical Name: (2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide
• CAS No.: 911051-19-9
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• Mol file: 911051-19-9.mol

Synonyms:(2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide

Chemical Property of (2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide

There total 1 articles about (2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonate(1R,2R,4R)-1-((R)-1-phenyl-ethyl)-2-((R)-1-phenyl-ethylcarbamoyl)-7-oxa-1-azonia-bicyclo[2.2.1]heptane; → (2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide (911051-19-9)

Guidance literature:

Methanesulfonate(1R,2R,4R)-1-((R)-1-phenyl-ethyl)-2-((R)-1-phenyl-ethylcarbamoyl)-7-oxa-1-azonia-bicyclo[2.2.1]heptane;; With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 19h; atmospheric pressure;

With Ambersep 900 (OH-); In methanol; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200600104

Reference yield: 87.0%

(2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide (911051-19-9) → (2R,4R)-4-hydroxy-N-[(1R)-1-phenylethyl]-2-piperidinecarboxamide

Guidance literature:

(2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide; With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 22h; atmospheric pressure;

With Ambersep 900 (OH-); In methanol; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200600104

Reference yield:

(2R,4R)-4-hydroxy-N,1-bis[(1R)-1-phenylethyl]-2-piperidinecarboxamide (911051-19-9) → (2R,4R)-4-hydroxy-2-piperidinecarboxylic acid (175671-49-5,189385-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / methanol / 22 h / 20 °C / atmospheric pressure

1.2: 87 percent / Ambersep 900 (OH-) / methanol / 2 h / 20 °C

2.1: 147 mg / HCl; water / 22 h / Heating

With hydrogenchloride; water; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1002/ejoc.200600104

Downstream raw materials:

(2R,4R)-4-hydroxy-2-piperidinecarboxylic acid