3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

Base Information

Chemical Name:3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid
CAS No.:1322757-98-1
Molecular Formula:C₁₆H₁₂ClNO₃S
Molecular Weight:333.795
Hs Code.:

Synonyms:3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

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Chemical Property of 3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

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Technology Process of 3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

There total 3 articles about 3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1322757-72-1
ethyl 3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylate

: 1322757-98-1
3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201100215

Reference yield:

: 882278-95-7
C₁₇H₁₆ClNO₂S₂

: 1322757-98-1
3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: 72 h / Inert atmosphere; Reflux

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 20 °C / Inert atmosphere

With water; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/ejoc.201100215

Reference yield:

: 1322757-53-8
ethyl 3-(4-chlorophenyl)-4-cyano-5-(isopropylsulfonyl)thiophene-2-carboxylate

: 1322757-98-1
3-(4-chlorophenyl)-4-cyano-5-(tetrahydrofuran-2-yl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 72 h / Inert atmosphere; Reflux

2: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 20 °C / Inert atmosphere

With water; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1002/ejoc.201100215