(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester
CAS No.:253800-11-2
Molecular Formula:C₂₀H₂₈O₆
Molecular Weight:364.439
Hs Code.:

Synonyms:(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

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Chemical Property of (E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

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Technology Process of (E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

There total 3 articles about (E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 253800-03-2
[(2R,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetaldehyde

: 253800-11-2
(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1055/s-1999-2922

Reference yield:

: 253800-02-1
<(2R,4R,6S)-6-methoxy-4-(4-methoxybenzyl)-oxy-tetrahydropyran-2-yl>-acetic acid methyl ester

: 253800-11-2
(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAH / tetrahydrofuran / 4 h / 20 °C

2: PCC / CH₂Cl₂ / 15 h / 20 °C

3: 91 percent / LiCl; DBU / acetonitrile / 2 h / 20 °C

With diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Reduction / 2: Oxidation / 3: Condensation;
DOI:10.1055/s-1999-2922

Reference yield:

: 2-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-ethanol

: 253800-11-2
(E)-4-[(2S,4R,6R)-6-Methoxy-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PCC / CH₂Cl₂ / 15 h / 20 °C

2: 91 percent / LiCl; DBU / acetonitrile / 2 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; lithium chloride; In dichloromethane; acetonitrile; 1: Oxidation / 2: Condensation;
DOI:10.1055/s-1999-2922