4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

Base Information

Chemical Name:4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl
CAS No.:945891-97-4
Molecular Formula:C₃₁H₂₂F₃N
Molecular Weight:465.518
Hs Code.:

Synonyms:4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

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Chemical Property of 4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

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Technology Process of 4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

There total 8 articles about 4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 945891-95-2
4-dimethylamino-2'-(2-phenylethynyl)-4-trifluoromethyl-5'-[2-(triisopropylsilanyl)ethynyl][1,1':4',1]terphenyl

: 945891-97-4
4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/ejoc.200700070

Reference yield:

: 945891-89-4
4-bromo-4'-trifluoromethyl-2,5-bis[2-(triisopropylsilyl)ethynyl]biphenyl

: 945891-97-4
4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: 29 percent / TBAF; acetic acid / tetrahydrofuran / 16 h / 20 °C

2: 86 percent / CuI; diisopropylethylamine / Pd(PPh₃)4 / tetrahydrofuran / 16 h / 20 °C

3: 84 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 16 h / 70 °C

4: 97 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2: Sonogashira coupling / 3: Suzuki coupling;
DOI:10.1002/ejoc.200700070

Reference yield:

: 945891-91-8
[2-(4-bromo-5-ethynyl-4'-(trifluoromethyl)biphenyl-2-yl)ethynyl]triisopropylsilane

: 945891-97-4
4-dimethylamino-5'-ethynyl-2'-(2-phenylethynyl)-4-trifluoromethyl[1,1':4',1]terphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / CuI; diisopropylethylamine / Pd(PPh₃)4 / tetrahydrofuran / 16 h / 20 °C

2: 84 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 16 h / 70 °C

3: 97 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Sonogashira coupling / 2: Suzuki coupling;
DOI:10.1002/ejoc.200700070