Technology Process of (8R,5Z)-8-(4-methoxybenzyloxy)deca-5,9-dienoic acid
There total 8 articles about (8R,5Z)-8-(4-methoxybenzyloxy)deca-5,9-dienoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
tetrahydrofuran; water; tert-butyl alcohol;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1039/c1ob05335c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: methanol; toluene-4-sulfonic acid / 1 h / 0 - 20 °C / Inert atmosphere
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
3: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 3 h / 0 - 20 °C / Inert atmosphere
With
methanol; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
3: Pinnick oxidation;
DOI:10.1039/c1ob05335c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: quinoline; hydrogen / benzene / 3 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -20 °C
2.2: 2.83 h / -20 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C / Inert atmosphere
4.1: methanol; toluene-4-sulfonic acid / 1 h / 0 - 20 °C / Inert atmosphere
5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
6.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 3 h / 0 - 20 °C / Inert atmosphere
With
quinoline; methanol; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; hydrogen; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexane; dichloromethane; water; mineral oil; tert-butyl alcohol; benzene;
6.1: Pinnick oxidation;
DOI:10.1039/c1ob05335c
