[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

Base Information

Chemical Name:[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane
CAS No.:444119-75-9
Molecular Formula:C₁₇H₂₉BrO₅Si
Molecular Weight:421.404
Hs Code.:

Synonyms:[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

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Chemical Property of [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

Chemical Property:

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Technology Process of [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

There total 5 articles about [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16534-12-6
3,5-dihydroxy-4-bromobenzoic acid

: 444119-75-9
[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: HCl gas

2: 1.) NaH / 1.) THF, DMF, 2.) THF, DMF

3: LiAlH₄ / tetrahydrofuran

4: imidazole / dimethylformamide

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 99-10-5
3,5-Dihydroxybenzoic acid

: 444119-75-9
[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; bromine / water / 3 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 65 °C

3.2: 2 h / Reflux

4.1: 1H-imidazole / dichloromethane / 14 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; bromine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.joc.1c02046

Reference yield:

: 167832-31-7
(methoxy)methyl 3,5-bis(methoxymethoxy)-4-bromobenzoate

: 444119-75-9
[4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 65 °C

1.2: 2 h / Reflux

2.1: 1H-imidazole / dichloromethane / 14 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.joc.1c02046