Technology Process of [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane
There total 5 articles about [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: HCl gas
2: 1.) NaH / 1.) THF, DMF, 2.) THF, DMF
3: LiAlH4 / tetrahydrofuran
4: imidazole / dimethylformamide
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; bromine / water / 3 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 65 °C
3.2: 2 h / Reflux
4.1: 1H-imidazole / dichloromethane / 14 h / 20 °C
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; bromine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.joc.1c02046
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0.25 h / 65 °C
1.2: 2 h / Reflux
2.1: 1H-imidazole / dichloromethane / 14 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.joc.1c02046
