ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

Base Information

Chemical Name:ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate
CAS No.:1202890-02-5
Molecular Formula:C₂₃H₂₄BrClO₆
Molecular Weight:511.797
Hs Code.:

Synonyms:ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

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Chemical Property of ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

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Technology Process of ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

There total 13 articles about ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1202890-01-4
ethyl 7-(2-amino-4-(tert-butoxycarbonyl)phenoxy)-8-bromo-6-chlorochroman-4-carboxylate

: 1202890-02-5
ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

Guidance literature:: With nitrous acid isobutyl ester; In N,N-dimethyl-formamide; at 68 - 70 ℃; for 0.583333h;

Reference yield: 17.0%

: 542-56-3
nitrous acid isobutyl ester

: 1202890-01-4
ethyl 7-(2-amino-4-(tert-butoxycarbonyl)phenoxy)-8-bromo-6-chlorochroman-4-carboxylate

: 1202890-02-5
ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 0.5h;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1202890-02-5
ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)phenoxy)-6-chlorochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

2.2: 1 h / 20 °C / Industry scale

3.1: sodium hydroxide / water / Industry scale

3.2: pH 2 - 3 / Industry scale

3.3: 16 h / Reflux

4.1: bromine / acetic acid / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 90 °C

6.1: ammonium chloride; zinc / tetrahydrofuran; water / 1 h / 20 °C

7.1: N,N-dimethyl-formamide / 0.5 h / 70 °C

With hydrogenchloride; tin(II) chloride dihdyrate; water; bromine; iodine; potassium carbonate; ammonium chloride; sodium hydroxide; zinc; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;