(1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

Base Information

Chemical Name:(1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate
CAS No.:1231895-58-1
Molecular Formula:C₂₄H₂₃F₃N₄O₄
Molecular Weight:488.466
Hs Code.:

Synonyms:(1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

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Chemical Property of (1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

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Technology Process of (1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

There total 1 articles about (1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1231895-49-0
(1r,4r)-ethyl 4-(3-fluoro-4-(2-hydrazinyl-2-oxoacetamido)-phenyl)cyclohexanecarboxylate

: 113028-75-4
3,4-difluorophenyl isothiocyanate

: 1231895-58-1
(1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

Guidance literature:: (1r,4r)-ethyl 4-(3-fluoro-4-(2-hydrazinyl-2-oxoacetamido)-phenyl)cyclohexanecarboxylate; 3,4-difluorophenyl isothiocyanate; In N,N-dimethyl-formamide; at 20 - 45 ℃;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 85 ℃; Product distribution / selectivity;

Reference yield: 96.0%

: 1231895-58-1
(1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate

: 1231895-43-4
(1r,4r)-4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylic acid

Guidance literature:: (1r,4r)-ethyl 4-(4-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)-3-fluorophenyl)cyclohexanecarboxylate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 72h;

With citric acid; In tetrahydrofuran; methanol; water; pH=4; Product distribution / selectivity;