ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

Base Information

Chemical Name:ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate
CAS No.:1589488-11-8
Molecular Formula:C₂₁H₂₄ClN₃O₅S
Molecular Weight:465.958
Hs Code.:

Synonyms:ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

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Chemical Property of ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

There total 6 articles about ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 1036436-17-5
3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoic acid

: 1589488-11-8
ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

Guidance literature:: 3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoic acid; With benzotriazol-1-ol; In dichloromethane; at 0 ℃; for 0.0833333h;

4-ethoxycarbonylpiperazine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 2h; pH=Ca. 8;
DOI:10.5012/jkcs.2013.57.6.731

Reference yield:

: 1589488-07-2
ethyl 4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine-1-carboxylate

: 106-47-8
4-chloro-aniline

: 1589488-11-8
ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

Guidance literature:: 4-chloro-aniline; With pyridine; In dichloromethane; at 0 ℃; for 0.0833333h;

ethyl 4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine-1-carboxylate; In dichloromethane; at 20 ℃;
DOI:10.5012/jkcs.2013.57.6.731

Reference yield:

: 99-94-5
p-Toluic acid

: 1589488-11-8
ethyl 4-(3-(N-(4-chlorophenyl)sulfamoyl)-4-methylbenzoyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / Cooling with ice

1.2: 5 h / Cooling with ice

2.1: chlorosulfonic acid / 6 h / 100 °C

3.1: pyridine / dichloromethane / 0.08 h / 0 °C

3.2: 20 °C

With pyridine; chlorosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.5012/jkcs.2013.57.6.731