2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

Base Information

Chemical Name:2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine
CAS No.:82995-79-7
Molecular Formula:C₃₀H₄₈N₆O₅Si₂
Molecular Weight:628.919
Hs Code.:

Synonyms:2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

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Chemical Property of 2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

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Technology Process of 2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

There total 4 articles about 2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 82995-80-0
2,6-diamino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

: 82892-54-4
1-(benzyloxycarbonyl)-3-ethylimidazolium tetrafluoroborate

: 82995-79-7
2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

Guidance literature:: With sodium hydrogencarbonate; In chloroform; Ambient temperature;
DOI:10.1021/jo00144a014

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 82995-79-7
2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / pyridine / 5 h / 0 - 20 °C

2: 85 percent / aq. NaOH / tetrahydrofuran; H₂O / 6 h / Ambient temperature

3: 56 percent / anhydr. ammonia / methanol / 24 h / 150 °C

4: 95 percent / aq. NaHCO₃ / CHCl₃ / Ambient temperature

With pyridine; sodium hydroxide; ammonia; sodium hydrogencarbonate; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1021/jo00144a014

Reference yield:

: 82995-89-9
2-amino-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>-6-(phenylthio)purine

: 82995-79-7
2-amino-6-<(benzyloxycarbonyl)amino>-9-<3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxy-β-D-erythro-pentofuranosyl>purine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / anhydr. ammonia / methanol / 24 h / 150 °C

2: 95 percent / aq. NaHCO₃ / CHCl₃ / Ambient temperature

With ammonia; sodium hydrogencarbonate; In methanol; chloroform;
DOI:10.1021/jo00144a014