6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

Base Information

Chemical Name:6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin
CAS No.:1154760-56-1
Molecular Formula:C₅₆H₈₀N₈O₂₃S
Molecular Weight:1265.36
Hs Code.:

Synonyms:6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

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Chemical Property of 6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

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Technology Process of 6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

There total 13 articles about 6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1154758-73-2
6'-PNZ-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

: 4403-36-5
2-phthalimido-ethanesulfonyl chloride

: 1154760-56-1
6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1154760-56-1
6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / 1,4-dioxane; water

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / -40 °C

3: 4-methyl-morpholine / tetrahydrofuran / 18 h / 0 °C

4: sodium hydroxide; sodium dithionite; ethanol; water / 18 h / 70 °C

5: N-ethyl-N,N-diisopropylamine / methanol / 1 h

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; sodium dithionite; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 32385-11-8
sisomicin

: 1154760-56-1
6'-PNZ-2'-(N-phthalimido-2-amino-ethylsulfonamide)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin

Guidance literature:: Multi-step reaction with 7 steps

1: nickel diacetate / methanol / 0 - 20 °C

2: zinc diacetate / methanol / 8 h / 0 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / -40 °C

4: 4-methyl-morpholine / tetrahydrofuran / 18 h / 0 °C

5: sodium hydroxide; sodium dithionite; ethanol; water / 18 h / 70 °C

6: N-ethyl-N,N-diisopropylamine / methanol / 1 h

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; sodium dithionite; ethanol; zinc diacetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; nickel diacetate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;