(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Chemical Name:(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
CAS No.:607731-95-3
Molecular Formula:C₂₇H₄₃NO₆Si
Molecular Weight:505.727
Hs Code.:

Synonyms:(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Chemical Property of (2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Technology Process of (2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 4 articles about (2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 607731-94-2
(2S,4R)-4-{2-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]ethyl}-5-oxopyrrolidine-2-carboxylic acid tert-butyl ester

: 607731-95-3
(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: (2S,4R)-4-{2-[dimethyl-(1,1,2-trimethylpropyl)silanyloxy]ethyl}-5-oxopyrrolidine-2-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -50 ℃; for 0.333333h;

benzyl chloroformate; In tetrahydrofuran; for 0.333333h;
DOI:10.1016/S0040-4020(03)01018-4

Reference yield:

: 365973-11-1
(2S,4S)-4-Allyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

: 607731-95-3
(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / sodium hydroxide / tetrahydrofuran; H₂O / 0.5 h / 20 °C

2.1: 99 percent / CH₂Cl₂ / 48 h / Heating

3.1: O₃ / methanol / 1.5 h / -60 °C

3.2: 80 percent / NaBH₄ / methanol

4.1: 98 percent / imidazole / dimethylformamide / 16 h

5.1: LiHMDS / tetrahydrofuran / 0.33 h / -50 °C

5.2: 80 percent / tetrahydrofuran / 0.33 h

With 1H-imidazole; sodium hydroxide; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)01018-4

Reference yield:

: 237421-63-5
tert-butyl (2S,4R)-4-(prop-2-enyl)-pyroglutamate

: 607731-95-3
(2S,4R)-4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethyl}-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / methanol / 1.5 h / -60 °C

1.2: 80 percent / NaBH₄ / methanol

2.1: 98 percent / imidazole / dimethylformamide / 16 h

3.1: LiHMDS / tetrahydrofuran / 0.33 h / -50 °C

3.2: 80 percent / tetrahydrofuran / 0.33 h

With 1H-imidazole; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)01018-4