[(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester
• CAS No.: 199340-84-6
• Molecular Formula: C₄₇H₈₂FN₇O₉
• Molecular Weight: 908.208

Synonyms:[(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Chemical Property of [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

There total 9 articles about [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

[(S)-5-Benzyloxycarbonylamino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (199340-83-5) → [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (199340-84-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h;

DOI:10.1016/S0968-0896(97)00137-5

Reference yield:

Spermine (71-44-3) → [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (199340-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 84 percent / H₂ / 10percent Pd/C / methanol / 4 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00137-5

Reference yield:

N2-benzyloxycarbonyl-N6-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester (2212-69-3) → [(S)-5-Amino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (199340-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / Et₃N / tetrahydrofuran / 2.5 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 84 percent / H₂ / 10percent Pd/C / methanol / 4 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(97)00137-5

upstream raw materials:

[(S)-5-Benzyloxycarbonylamino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Spermine

L-4-fluorophenylalanine

N₂-benzyloxycarbonyl-N₆-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester

Downstream raw materials:

[(S)-5-(3-{tert-Butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-5-(2,2,2-trifluoro-acetylamino)-pentyl]-carbamic acid tert-butyl ester

[(S)-5-Acetylamino-5-(3-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-{3-[(S)-3-(4-fluoro-phenyl)-2-heptanoylamino-propionylamino]-propyl}-amino)-butyl]-amino}-propylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

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