(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

Base Information

Chemical Name:(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one
CAS No.:198147-94-3
Molecular Formula:C₂₅H₄₀N₂O₅Si
Molecular Weight:476.688
Hs Code.:

Synonyms:(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

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Chemical Property of (2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

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Technology Process of (2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

There total 1 articles about (2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-07-0,9002-91-9
acetaldehyde

: 198147-93-2
(5S)-1-[(4S)-(2-oxo-4-phenyl-1,3-oxazolidin-3-yl)]-5-(triisopropylsilyloxy)-2-trimethylsilyloxy-3-azahexa-1,3-diene

: (2R,5R,6R)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

: 198147-94-3
(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 3h; Yield given. Yields of byproduct given;
DOI:10.1021/jo971395g

Reference yield:

: 198147-94-3
(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

: [(2R,5S,6S)-6-Methyl-4-oxo-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-5-yl]-carbamic acid benzyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; Yield given;
DOI:10.1021/jo971395g

Reference yield:

: 198147-94-3
(2R,5R,6S)-6-Methyl-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-((S)-1-triisopropylsilanyloxy-ethyl)-[1,3]oxazinan-4-one

: 98777-34-5
(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / dimethylformamide / 80 °C

2: HCl / 0.5 h / 0 °C

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide;
DOI:10.1021/jo971395g