(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

Base Information

Chemical Name:(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester
CAS No.:294842-92-5
Molecular Formula:C₂₄H₃₂NO₈P
Molecular Weight:493.494
Hs Code.:

Synonyms:(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

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Technology Process of (S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

There total 1 articles about (S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140196-38-9
1,1-dimethyl (2-oxo-1-phenylethyl)carbamate

: 294842-92-5
(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / Et₃N / 24 h / 20 °C

2: 33 percent / DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; 1: Addition / 2: Esterification;
DOI:10.1016/S0957-4166(00)00203-2

Reference yield: 92.0%

: 294842-92-5
(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

: 294842-98-1
dimethyl (1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-hydroxy-2-phenylethylphosphonate

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(00)00203-2

Reference yield:

: 294842-92-5
(S)-Methoxy-phenyl-acetic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(dimethoxy-phosphoryl)-2-phenyl-ethyl ester

: dimethyl (1S,2S)-2-(benzoylamino)-1-hydroxy-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 25 percent aq. NH₄OH / tetrahydrofuran / 2 h / 20 °C

2: 57 percent / Et₃N; DMAP

3: 73 percent / HCl / ethyl acetate; CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; dmap; ammonium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: deesterification / 2: benzoylation / 3: Rearrangement;
DOI:10.1016/S0957-4166(00)00203-2