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Technology Process of (2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

Base Information
  • Chemical Name:(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene
  • CAS No.:80115-04-4
  • Molecular Formula:C35H49ClO
  • Molecular Weight:521.226
  • Hs Code.:
(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

Synonyms:(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

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Chemical Property of (2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene
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Technology Process of (2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

There total 4 articles about (2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
80115-01-1

(5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene
80115-04-4

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

Guidance literature:
With monoperoxyphthalic acid; In diethyl ether; chloroform; for 40h; Ambient temperature;
DOI:10.1055/s-1981-29543

Reference yield:

2-chlorophenylacetylene
873-31-4

2-chlorophenylacetylene

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene
80115-04-4

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

Guidance literature:
Multi-step reaction with 3 steps
1: 75 percent / 1.) Mg, C2H5Br / 1.) Et2O, reflux, 3h, 2.) Et2O, reflux, 2h
2: HClO4 / benzene / 0.03 h / Heating
3: 73 percent / Monoperoxophthalsaeure / CHCl3; diethyl ether / 40 h / Ambient temperature
With ethyl bromide; perchloric acid; monoperoxyphthalic acid; magnesium; In diethyl ether; chloroform; benzene;
DOI:10.1055/s-1981-29543

Reference yield:

dihydrocholesterone
566-88-1

dihydrocholesterone

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene
80115-04-4

(2R,3R,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthrene

Guidance literature:
Multi-step reaction with 3 steps
1: 75 percent / 1.) Mg, C2H5Br / 1.) Et2O, reflux, 3h, 2.) Et2O, reflux, 2h
2: HClO4 / benzene / 0.03 h / Heating
3: 73 percent / Monoperoxophthalsaeure / CHCl3; diethyl ether / 40 h / Ambient temperature
With ethyl bromide; perchloric acid; monoperoxyphthalic acid; magnesium; In diethyl ether; chloroform; benzene;
DOI:10.1055/s-1981-29543
upstream raw materials:

(5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene

2-chlorophenylacetylene

dihydrocholesterone

(3S,5S,8R,9S,10S,13R,14S,17R)-3-(2-Chloro-phenylethynyl)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-ol

Downstream raw materials:

5'-(2-Chlorphenyl)-5α-cholest-2-eno<2,3-b>furan

(5S,8R,9S,10S,13R,14S,17R)-3-[2-(2-Chloro-phenyl)-acetyl]-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-2-one

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