tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

Base Information

Chemical Name:tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate
CAS No.:1287234-55-2
Molecular Formula:C₂₂H₂₉BrN₂O₃
Molecular Weight:449.388
Hs Code.:

Synonyms:tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

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Chemical Property of tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

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Technology Process of tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

There total 7 articles about tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287234-54-1
tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methyl-2-(naphthalen-2-ylmethyleneamino)propanoate

: 1287234-55-2
tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1039/c0ob00991a

Reference yield:

: 1287234-51-8
6-bromo-2,4-dimethyl-5-acetoxymethyl-3-benzyloxypyridine

: 1287234-55-2
tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol / 0.5 h / 20 °C

2: thionyl chloride / chloroform / 0.17 h / 20 °C

3: tetrabutylammomium bromide; potassium hydroxide / dichloromethane / 2 h / 20 °C

4: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; tetrabutylammomium bromide; water; sodium methylate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1039/c0ob00991a

Reference yield:

: 1287234-50-7
6-bromo-2,4-dimethyl-5-acetoxymethyl-3-hydroxypyridine

: 1287234-55-2
tert-butyl 2-amino-3-(6-bromo-2,4-dimethyl-3-benzyloxypyridin-5-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 2 h / Reflux

2: sodium methylate / methanol / 0.5 h / 20 °C

3: thionyl chloride / chloroform / 0.17 h / 20 °C

4: tetrabutylammomium bromide; potassium hydroxide / dichloromethane / 2 h / 20 °C

5: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; tetrabutylammomium bromide; water; sodium methylate; sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1039/c0ob00991a