diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate

Base Information

• Chemical Name: diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate
• CAS No.: 1030320-77-4
• Molecular Formula: C₂₄H₂₃IO₅
• Molecular Weight: 518.348
• Mol file: 1030320-77-4.mol

Synonyms:diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate

Chemical Property of diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate

Chemical Property:

Purity/Quality:

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Technology Process of diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate

There total 1 articles about diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2-iodophenyl)propanedioic acid diethyl ester (128823-22-3) + 1-(4-(3-bromoprop-1-yn-1-yl)phenyl)ethanone (731785-24-3) → diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate (1030320-77-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200701043

Reference yield: 91.0%

diethyl 2-[3-(4-acetylphenyl)prop-2-ynyl]-2-(2-iodophenyl)malonate (1030320-77-4) + phenylboronic acid (98-80-6) → diethyl (E)-3-[(4-acetylphenyl)(phenyl)methylene]-2,3-dihydroindene-1,1-dicarboxylate (1030321-02-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200701043

upstream raw materials:

(2-iodophenyl)propanedioic acid diethyl ester

1-(4-(3-bromoprop-1-yn-1-yl)phenyl)ethanone

Downstream raw materials:

diethyl (E)-3-[(4-acetylphenyl)(phenyl)methylene]-2,3-dihydroindene-1,1-dicarboxylate