methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

Base Information

Chemical Name:methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate
CAS No.:1268474-64-1
Molecular Formula:C₁₁H₁₃ClN₄O₅
Molecular Weight:316.701
Hs Code.:

Synonyms:methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

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Chemical Property of methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

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Technology Process of methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

There total 1 articles about methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256446-67-0,819078-65-4
4-((benzyloxy)carbonyl)morpholine-3-carboxylic acid

: 1268474-64-1
methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 18 h / 34 - 50 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 5.03 h / -70 - -40 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 760.05 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -10 - 20 °C

With sulfuric acid; hydrogen; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 1268474-64-1
methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

: 1268473-76-2
1-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr

2: potassium carbonate / dimethyl sulfoxide / 2.5 h / 20 - 35 °C

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.67 h / 100 °C / Microwave Irradiation

With methanol; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(acetylacetonate)oxovanadium; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 1268474-64-1
methyl 4-(2-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine-3-carboxylate

: 1268473-82-0
1-cyclopropyl-3-(4-(5-(cyclopropylmethyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr

2: potassium carbonate / dimethyl sulfoxide / 2.5 h / 20 - 35 °C

3: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.95 h / 100 - 110 °C

With methanol; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(acetylacetonate)oxovanadium; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;