C₂₁H₂₂F₂N₄O₄

Base Information

Chemical Name:C₂₁H₂₂F₂N₄O₄
CAS No.:1330075-76-7
Molecular Formula:C₂₁H₂₂F₂N₄O₄
Molecular Weight:432.427
Hs Code.:

C<sub>21</sub>H<sub>22</sub>F<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

Synonyms:C₂₁H₂₂F₂N₄O₄

Suppliers and Price of C₂₁H₂₂F₂N₄O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₂₂F₂N₄O₄

Chemical Property:

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Technology Process of C₂₁H₂₂F₂N₄O₄

There total 7 articles about C₂₁H₂₂F₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 120153-08-4
4-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1349192-83-1
C₁₄H₁₈BrFN₄O₂

: 1330075-76-7
C₂₁H₂₂F₂N₄O₄

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃;
DOI:10.1016/j.bmcl.2011.05.115

Reference yield:

: 1034621-87-8
3-(3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)propan-1-ol

: 1330075-76-7
C₂₁H₂₂F₂N₄O₄

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide

2: triethylamine / dichloromethane / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 °C

4: trifluoroacetic acid / dichloromethane

5: dmap / dichloromethane

6: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 90 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 6: Suzuki-Miyaura coupling reaction;
DOI:10.1016/j.bmcl.2011.05.115

Reference yield:

: 1330075-99-4
C₁₇H₁₈BrFN₄O

: 1330075-76-7
C₂₁H₂₂F₂N₄O₄

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane

2: dmap / dichloromethane

3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 90 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 3: Suzuki-Miyaura coupling reaction;
DOI:10.1016/j.bmcl.2011.05.115